Thursday 8th December 2016 - 13.00 to 14.00
University of Glasgow - Wolfson Medical School
Gannochy Lecture Theatre, Room 248 Wolfson Medical School Building,University Place, Gilmorehill Campus, Glasgow G12 8QQ
Thursday 8th December 2016 - 15.00 to 16.00
University of Glasgow - Wolfson Wohl Cancer Research Centre
Seminar Room, Wolfson Wohl Cancer Research Centre, Garscube Estate, Switchback Road, Bearsden, G61 1QH
Friday 9th December 2016 - 12.00 to 13.00
University of Aberdeen - Level 5 conference room - Institute for Medical Sciences (IMS), Forrester Hill Campus, Aberdeen AB25 2ZD
We are looking for biologists and clinicians with phenotypic assays or assay-concepts, that are interested in translating their research. We offer the opportunity to get these assays screened to industry standards against best-in-class small molecule compound libraries. In this seminar we will present the opportunities for assay development and phenotypic screening that are available at NPSC.
NPSC is a world-class facility for phenotypic screening run by an interdisciplinary team of scientists and engineers who collaborate to advance the use of complex biology and to drive innovation. NPSC was set up to complement the activities of the target-based screening centres, taking a more holistic approach to understanding disease at the cellular and tissue level. Focused on using “high-content” image-based approaches to hit discovery, initial emphasis will be on tackling complex, multi-faceted diseases, employing the most physiologically relevant assays possible.
Screens are performed using high quality compound collections to generate either new understanding of disease pathology and toolbox reagents for further academic use, or validated chemical start points for pre-clinical drug development. Phenotypic assay development will take place as a joint effort between the NPSC and the academic lab or clinician, thereby bridging the gap between early stage data and an industry-standard assay.
In addition to being accessible via existing funding routes, the NPSC has established the Phenomics Discovery Initiative (PDi), a public-private partnership between industrial pharmaceutical companies and NPSC. PDi seeks to identify, develop, screen and validate innovative phenotypic assays that are relevant to human disease. PDi phenotypic assays are recruited from proposals made by academics, clinicians and SMEs. Selected proposals are screened free of charge.
Phenotypic screening embraces the complexity of organisms, tissues and cells in order to identify bioactive agents such as small molecules and antibodies. Rather than being focused on biochemical assays on an isolated target molecule, it relies on a more holistic and empirical approach often using live cell assay systems. When integrated early in the drug discovery process, phenotypic screening hits can progress faster as they already act in the correct context, improving success rates for lead selection/optimization, and reducing failure in phase II and III due to poor safety and low efficacy.
The project will enable a unique collaboration bringing together expertise at Dundee in male fertility and drug discovery to help identify possible new male contraceptive drugs.
Cambridge, MA - 31st October to 2nd November 2016.
Neil Carragher, Paul Andrews and Denise Barrault from PDi and NPSC presented work carried out at the NPSC at the longest-running High-Content Analysis & 3D Screening Conference in Cambridge, MA.
SelectBio High Content & Phenotypic Screening 2016 - Cambridge, 10th and 11th May 2016.
This conference brings together researchers from both academia and industry, and will discuss the development of techniques and tools implemented in High Content technologies and Phenotypic Screening applications.
Axol Biosciences Ltd, the Cambridge-based biotechnology company specialising in the use of stem cell technology to manufacture disease relevant cell based assay systems for the drug discovery industry, recently announced the appointment of Dr. Paul Andrews, NPSC's Director of Operations to their Scientific Advisory Board (SAB). Paul's appointment follows on from NPSC's ongoing collaborations to use Axol's neural progenitor cells for drug discovery. The other members of the SAB are Chris Torrance (Horizon Discovery), Steve Rees (AstraZeneca), Chas Bountra (SGC/University of Oxford) and Darren Disly (Horizon Discovery Group)
Seattle, WA – January 25, 2015
The technology for viewing, sharing, analysis and management of large sets of images and metadata will enable new collaborations and research.
Glencoe Software, the world-leading supplier of image data management solutions for biotech, pharma and publication industries, will provide the data management solution OMERO Plus for the newly established National Phenotypic Screening Centre (NPSC). Phenotypic analysis measures the characteristics and behavior of cells, tissues and even whole organisms, allowing comparisons between states such as health and disease, the presence or absence of toxins or drugs, or the effect of genetic mutants. A key challenge for NPSC is the development of automated workflows or “smart assays” that combine robotics with the use of advanced informatics and decision analytics in real-time to screen large numbers of potential drugs as efficiently and effectively as possible. NPSC is a highly collaborative environment with multiple partners worldwide requiring data sharing to be seamless and secure. To deliver on these requirements, NPSC has chosen Glencoe Software’s OMERO Plus data management, storage and integration technology to meet this challenge.